Endocrine Abstracts

Diabetes mellitus type 2 (DM-2) is a disorder characterized by high blood glucose levels in the context of insulin resistance and relative insulin deficiency. DM-2 is typically an outcome of combinations of hereditary elements of impaired insulin release and insulin resistance, and natural variables like obesity, overeating, absence of activity, aging and stress. A number of hormones, such as cortisol and growth (GH), have insulin-antagonistic effects. Cortisol is a predominan...

Ghrelin, a putative signal of insufficient energy stores, increases in fasting states, decreases postprandially, and acts as a potent appetite stimulant increasing food intake. Obestatin affects appetite, food preferences to increase daily caloric intake and weight gain. Leptin regulates body fat mass, food intake and energy expenditure. Triiodothyronine (T3) is a determinant of adiposity, thermogenesis, glucose and lipid metabolism, appetite, food intake, and the o...